ABSTRACT
Objective To discuss the determination of estriol and placenta prolactin levels for fetal grow th and development and provide theoretical basis for doctors to improve the rate of eugenic and superior nurture .Methods The pregnant women treated in the hospital from August 2014 and February 2015 were divided into two groups :pregnant women with fetal growth restriction were as the observation group(n=59) ,who with normal fetal development were as control group(n=256) .Estriol and placenta prolactin levels of two groups tested ,and the data obtained were statistically analyzed .Results Estriol level of the observation group was (13 .36 ± 2 .57)ng/mL ,which of the control group was (21 .34 ± 3 .48)ng/mL ,and the level of the observation group was lower than the control group significantly(P<0 .05) .Placenta prolactin concentration of the observation group was (3 .28 ± 0 .84)ng/mL , taht of the control group was (5 .27 ± 1 .24) ng/mL ,and the level of the observation group was lower than the control group signifi‐cantly(P<0 .05) .Estriol positive rate of observation group was 40 .68% (24/59) ,placenta prolactin positive rate was 37 .29%(22/59) ,and the positive rate of combined detection was 71 .19% (42/59) .Conclusion Examination the estriol and placenta prolac‐tin levels of pregnant female can evaluate fetal placental function .
ABSTRACT
Objective To investigate the serum sex hormone changes and fertility condition in childbearing age women patients with hyperthyroidism treated by iodine-131 .Methods 50 cases of healthy volunteers were selected .248 childbearing age women pa-tients with hyperthyroidism were divided into the iodine-131 group and the anti-thyroid medication group according to the treatment method .The thyroid function and gonad hormone before treatment and at 6 months after treatment were detected in 3 groups ,and the pregnancy and fetal condition were tracked .Results The change of thyroid stimulation hormone(TSH) level was more sensitive in the iodine-131 treatment group than the anti-thyroid medication group ;luteinizing hormone(LH) ,follicle stimulation hormone (FSH) ,prolactin(PRL) ,testosterone(T) and progesterone(P) before treatment in the two groups were significantly increased com-pared with the control group ,but E2 was decreased ;the changes of sex hormones in the iodine-131 treatment group had differences between before and after treatment ,the changes of T and P in the anti-thyroid medication group were unobvious before and after treatment ;the normal delivery rate in the control group and the iodine-131 therapy group had no statistical difference (χ2 =0 .148 , P=0 .7>0 .05) ,the normal delivery rate in the control group and the anti-thyroid medication group had statistically significant difference(χ2 = 5 .739 ,P=0 .017<0 .05) ,the normal delivery rate in the iodine-131 therapy group and the anti-thyroid medication group had statistically significant difference(χ2 =4 .26 ,P=0 .039<0 .05) .Conclusion The iodine-131 therapy has no influence on the sex hormones and the fertility ability in childbearing age women patients with hyperthyroidism ,and also does not increase the incidence rate of genetic damage .
ABSTRACT
Objective To study the early diagnosis of heamolytic disease of newborn(HDN) by umbilical blood immunoserological test. Methods According to the laboratory rules, immunoserological tests were practised with neonatal umbilical blood of 916 A or B blood-type neonates delivered by O-type blood mothers. The morbidity and the pathogenic time of hyperbilirubinemia were studied in 7 days after birth to the neonates whose erythrocyte was sensitized by the anti-A(B) IgG. Results (1) There was significant difference in the morbidity of hyperbilirubinemia of the neonates whose umbilical blood antibody-released test results were postive compared with control group (P<0.01), There had no significant difference in the morbidity of hyperbilirubinemia of the neonates compared with puerperal times. (2) There had significant difference in the morbidity of hyperbilirubinemia between the neonates having free antibody and those without free antibody (P < 0.01). (3) The peek time of hyperbilirubinemia was in 1-3 days after birth in patient-infants whose antibodyreleased test result was positive. Conclusion The umbilical blood immunoserological test is an exact method of the early diagnosis to HDN. The free antibody helps to estimate the developing trend of HDN.